Study, year

Patients (N)

Outcomes

McLaughlin, 1988 [6]

333

-Study design: systematic review of 333 MBC cases to assess the incidence by occupational and industrial categories

-The highest occupational risk (SIR = 7.6) was seen in men employed in the soapand perfume-making industry (p < 0.01)

Cocco, 1998 [21]

1219

-Study design: case-control study of 178 cases of MBC and 1041 controls to investigate risk of MBC with workplace exposures

-Increase in MBC risk associated with employment in blast furnaces, steel works, and rolling mills (OR = 3.4, 95% CI: 1.1 - 10.1)

-Increase in MBC risk associated with employment in the MVI (OR = 3.1, 95% CI: 1.2 - 8.2)

Hansen, 2000 [28]

13,110

-Study design: case-control study of 230 cases and 12,880 controls on the association between MBC morbidity and occupational exposure

-OR = 2.5 (95% CI: 1.3 - 4.5) for men with >3 months of employment in occupations with potential exposure to gasoline and combustion products

-OR = 5.4 for men employed at <40 years of age (95% CI: 2.4 - 11.9)

Villeneuve, 2010 [27]

2005

-Study design: investigation of MBC occupational risk factors in a case-control study of 104 cases and 1901 controls

-Increased MBC risk in motor vehicle mechanics (OR = 2.1, 95% CI: 1.0 - 4.4), with increased risk if employed ≥10 years (OR = 5.9, 95% CI: 2.4 - 14.6)

-Increased risk in sale/repair of motor vehicles (OR = 1.8, 95% CI: 1.0 - 3.2)

Sun, 2013 [34]

Meta-analysis

-Study design: a meta-analysis of 7 case-control and 11 cohort studies to confirm a possible association between MBC and EMF exposure

-Increased risk of MBC with EMF exposure was defined (pooled ORs = 1.32, 95% CI: 1.14 - 1.52, p < 0.001)